Hmm, yeah, La Borra is powerful but not really overwhelmingly so; definitely not as strong as Vandalier, but still very strong.
I've been doing runs without the first row of powerups - so no innate +damage, +armor, +HP and +regen, which has definitely added some challenge back in. Any damage that slips through is a lot more threatening so you have to be very careful. Although, I was doing a run in hyper library last night with Mortaccio and made it to ~20 minutes, when suddenly I just...died. Didn't see anything by my body, I just ceased to be. One of the suicide bomber banshees must have snuck through, but I had several maxed or evolved weapons by then so I'm not sure how? Ah well.
One way to make up for the lack of those bonuses is use the character that fills them, so I did a hyper forest run with the Cleric and made it through. +HP and +regen covered, and I ended up grabbing spinach too since I found myself with the fire wand. For an unplanned build grabbing whatever seemed OK at the time, I ended up evolving La Borra, Hellfire, Reaper axes, Holy sword, Unholy vespers, and maxed rune tracer. The only risk I was really in by the end was during the very last crush of glowing bats, when one-four of them might push through the Bibles and reach me, especially if I took a step in any direction. I'll be trying Mortaccio again next. Maybe then I'll try the reverse - Use the first row but skip the passive accessories for duration, cooldown, etc.