In Resident Evil, the main areas (the mansion, the outside residence and the labs) are small, but dense. There's always a safe room at relative close distance, enemies have predictable patterns which you can learn to help avoid them and save ammo, and great care is taken in placing necessary puzzle items and ammo in places where it won't be an inconvenience to drop things off if you need to. Even playing as Chris, the lack of inventory space is a minor inconvenience at best.
Signalis has densely packed areas as well, but getting to your item box tends to be a chore; of the two areas I've played, there's been one storage box at the beginning with one you can unlock later, and you get all of six slots, two of which will be taken up by a gun and ammo most likely. This is the same as Chris in RE1, however, a few of the specific mechanics make this space seem like way more of a chore; For one, the game is *packed* with enemies. At first blush the areas were wide open enough that dodging enemies, but soon they crowd the space and make dodging almost impossible in places. The game gives a couple of options with dealing with enemies: shooting them (no melee weapons here), or a defensive item. Ammo seems plentiful, except that rather than having a set amount like RE, pick ups can contain as little as 2 bullets. Defensive items work similar to the knife in REmake, allowing you to down an enemy temporarily to escape without taking damage. However, unlike REmake, they take up an inventory slot. They also need to be equipped like weapons - but other things need to be equipped in this slot too, such as a flashlight or camera required for certain puzzles, which also require inventory slots.
So if avoiding enemies is too dangerous, and defensive items are a pain, there's taking enemies out. It eats bullets, but at least then they're gone, right? Nope - even when taken out with a weapon, enemies will eventually get back up, requiring once again for you to not get hit or wasting more ammo/defensive items. And this will more than likely happen often, as the amount of running back and forth through areas you have to do is only added by the lack of storage boxes. There is an option to keep them from getting back up; thermite, which burns the body, just like using kerosene and a lighter in REmake to stop zombies from becoming crimson heads. There's a couple differences though - in REmake, you either used Jill and had a lighter and the flask take up two slots, or you used Chris and had the lighter auto-equipped (balancing out Chris' lack of inventory space) - here, the thermite takes up yet another space of your Chris like inventory *and* needs to be sub-equipped like a defensive item. Secondly, as long as you keep track of where the kerosense refill spots are (usually near an item box) and only take out zombies you really need to, a much easier ask in REmake, then you'll have plenty of flask charges to never really have to deal with Crimson Heads. I've found... four? maybe five thermite charges in total so far, and there are rooms that have up to four enemies in them. And even if you decide to deal with the Crimson Heads, once they're dead, they're gone. Here, you HAVE to burn the enemies to get them to stay down for good.
Healing items are somewhat common in Signalis, though usually I feel like I have to forgo picking them up due to lack of inventory space or use them really inefficiently because the health system is extremely unclear in this game. It has a similar EKG meter like RE, and your character will show when your damage is low on their person, however few healing items immediately restore your health. Instead, they heal 'over time', though over how much time and how much overall, I'm still not entirely sure about. There is one item (technically two including the full heal item) that will restore health instantly, but it's a rare find - or you can make it by combining a small heal item and a large heal item, though that actually requires being able to put the two in your inventory at some point. And usually I'm hurting by an unspecified amount and I know I'm not going to get healed right away, that I usually just use the low health items immediately and don't even bother mixing the items anyway.
