After finishing Cyberpunk 2077 (110 hours) I still wanted to play with such an itch that I started a second character the same day I rolled the second ending. I expected to peter out partway through that playthrough, but I not only completed the run, I did it even more thoroughly than my first run (120 hours). So it's time to put it down and move on to—oops no I have now started a third character and am still Very Into It. I highly doubt anything will come close to unseating it as my game of the year. IF I can tear myself away to play anything else in the first place...
My first was a "stealth archer" build - sniper rifles and silenced pistols for sneaking and headshots, and a time-slowing sandevistan mod with a fire-bullet pistol for tougher enemies and groups. Played on Normal difficulty, and after a brief period of adjustment at the beginning, once my build came online, the game became surprisingly—even disappointingly—easy. Like I'd be getting headshots for around 2000 damage on baddies, but if I missed the headshot and only hit them for 400... they'd still die in that one hit. Welp! I got two endings and decided to save the others for my next playthrough.
My second was a "Tanky Mage," accidentally replicating my favorite fantasy game archetype in the cyberpunk genre (I didn't realize I had done so until about halfway through). Focused on Intelligence and hacking (ie basically spellcasting), using her brain to set gonks on fire or short circuit robots from a distance, but also in Body and blunt melee combat, using either an iconic golden baseball bat or her gorilla arms to charge around, knocking fools down, ground slamming, and generally just beating people to death with her bare hands (while still also hacking). It was fun, but even on Hard difficulty the game got pretty easy by the end, where a single Overheat would KO most basic enemies and a doublestack of poison would take out entire groups; only a few of huge encounters and bosses in the endgame really put up a fight. I ended up getting the other three main endings and went the other direction in the DLC from the first time, so I've seen most or all of the story options by now (notwithstanding the minor differences like doing the same ending with a different love interest).
Third build is "pointy things" - dual specialization in throwing blades (knives for now but I wanna try out throwing axes too) for stealth headshots and swords for wading into combat (katana for now but I wanna try out a chainsword too), zipping around with air dash and double-jump, deflecting bullets back at their heads, and slicing fools up. I tried Mantis Blades (the ones that pop out of your cyber arms) but they seemed a lot slower and more unwieldy than a regular old katana so I'm sticking to those for now, but might try the mantis again later on when I unlock a late-game extra perk system for them. I started on Very Hard but before my build came online it was a little too tough, so I dropped it to hard until I started owning bones and now I'm back on Very Hard, which is actually a satisfying level of difficulty - if things get out of hand and I get swarmed I'll probably get gunned down relatively easily, but if I'm good about stealthily picking people off and choosing my battles and using my environment, I can get past most encounters without too much trouble.
As for the transphobia discussion... I know the marketing phase saw CDPR trip over their own dicks and offend the trans community a couple times, and I'm not excusing that (though looking into the tweets themselves, they strike me as Stupid But Not Malicious, but I won't spend effort trying to justify it - the remarks hurt people and that's what matters most). But the game itself comes off as actually pretty inclusive. You can make your player character trans easily, mixing and matching any combination of voice, build/upper body and genitals that you want. There are at least two trans characters with relatively major roles, both represented as trans but not made a big deal of or fetishized or anything, played by actual trans voice actors, and I believe some minor/side characters as well. There's a risque in-game ad poster or two that some critique as being oversexualized—which is true, but almost every ad in the game is oversexualized, there's T&A everywhere you look, it's a sleazy oversexualized world they've built. Ironically, including a fetishized/sexualized trans-person ads as part of the background feels to me more inclusive than othering, in context of how they designed the overall culture of the city. SO I dunno. I'm a cis guy, so take my opinion for what it's worth. I'm not telling anyone to stop their boycott, and I understand where the arguments against CDPR are coming from as well—I went and read some articles from the time to challenge my viewpoint and make sure I understood the opposition. I just think at the end of the day that the game itself says something different than the opposition to it portrays it as.